Dr Mpho Choene

Overview

Dr Choene's research interest is in the identification of South African medicinal plants in the quest to developing novel cancer therapeutics. Natural products have been playing a significant role in drug discovery as a source of potential cytotoxic agents. Our research involves the identification, isolation and characterization of bioactive compounds from natural compounds and the elucidation of their anticancer mechanism. LINKS: Google scholar link : https://scholar.google.com/scholar?start=0&q=choene+mpho&hl=en&as_sdt=0,5 Orcid Profile : https://orcid.org/0000-0001-5251-8010 Research articles : Raphela-Choma, P.P., Lukhwareni, R., Simelane, M.B.C. L. R. Motadi & M. S. Choene (2024). Antitumor effect of Iso-mukaadial acetate on MCF-7 breast cancer mice xenograft model. Scientic Reports 14, 13744 Myoli A, Choene M , Kappo AP, Madala NE, van der Hooft JJJ, Tugizimana F. (2024) Charting the Cannabis plant chemical space with computational metabolomics. Metabolomics. 20(3):62. Fatima Hoosen, Jordan Tonga Lembe, Derek Ndinteh, Tagatsing Fotsing Maurice, Yankep Emmanuel, Lesetja Raymond Motadi and Mpho Susan Choene (2024). The anti‑cancer potential of active compounds extracted from Millettia griffoniana on pancreatic and colorectal cancer cells. Advances in Traditional Medicine MM Lephatsi , MS Choen e , AP Kappo , NE Madala and F Tugizimana (2023). An Integrated Molecular Networking and Docking Approach to Characterize the Metabolome of Helichrysum splendidum and Its Pharmaceutical Potentials. Metabolites. 13(10):1104 SC Makuwa , LR Motadi, M Choene , Y Liu and MH Serepa-Dlamini (2023). Bacillus dicomae sp. nov., a new member of the Bacillus cereus group isolated from medicinal plant Dicoma anomala . Int J Syst Evol Microbiol. 73(10) Portia Raphela-Choma, Mthokozisi BC Simelane and Mpho S Choene (2022). Evaluation of the antiproliferative effect of Iso-mukaadial acetate on breast and ovarian cancer cells. Advances in Traditional Medicine . Lesetja R Motadi, Mpho S Choene , and Nonkululeko N Mthembu (2020). Anticancer properties of Tulbaghia violacea regulate the expression of p53-dependent mechanisms in cancer cell lines. Scientific Reports . 10(12924) Mpho S Choene and Lesetja R Motadi (2016). Validation of the antiproliferative effects of Euphorbia tirucalli extracts in breast cancer cell lines. J. Mol Bio . 50(3): 115-128 Njende Ubanako, Mpho Choene and Lesetja Motadi (2015). Mechanisms of Apoptosis in Ovarian Cancer: the Small Molecule Targeting. Int. J. Med. Med. Sci. 7(3): 46-60 Pontsho Moela, Mpho S. Choene , Lesetja R. Motadi (2014). Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death . Immunobiol . 219: 593–601