Prof Lesetja Motadi

Overview

Prof Motadi’s cancer genomics and apoptosis including focuses on targeted therapy and immunotherapy in cancer. The research focuses on using cancer patient-derived Ex vivo cells to monitor the response to both therapeutic agents synthesized from natural products. We further look at the biomarkers identified from patient-derived cells as possible therapeutic agents in combination with conventional cancer therapies to reduce the side effects and improve the effectiveness of the therapy. LINKS Google scholar : https://scholar.google.com/citations?hl=en&view_op=list_works&gmla=AC6lMd8-POJautekA96BB12sHQv7b6_nl_5Ami2eB3g4S3V7QuPIfLyjFTxKG1XjWFhUFhfl5rbIpUn7KijWoA&user=be8Uf6kAAAAJ ORCID : https://orcid.org/my-orcid?orcid=0000-0001-6012-6367 Research articles: ST Lukhele, LR Motadi (2016). Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells. BMC complementary and alternative medicine, 2016 LR Motadi, MS Choene, NN Mthembu (2020). Anticancer properties of Tulbaghia violacea regulate the expression of p53-dependent mechanisms in cancer cell lines. Scientific reports, 2020 Cannabidiol and Cannabis Sativa as a potential treatment in vitro prostate cancer cells silenced with RBBp6 and PC3 xenograft. Molecular biology reports 50 (5), 4039-4047 RBBP6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses. Cancer Management and Research, 3357-3369 George A Asare, Bernice Asiedu, Vivash Naidoo, Josephine Ablakwa, Samuel Adjei, Brodrick Amoah, Richard Obeng-Kyeremeh, Lesetja Motadi, Mokbul Hossain, Munmun Parveen, Antora Akter, Mahmudul Alam, Mohammed Habibur Rahman (2024). The impact of combination therapy of Croton membranaceus and finasteride on benign prostatic hyperplasia (BHP) histo-morphology. Phytomedicine Plus 4 (2), 100543